Each metabolite, regardless of its molecular simplicity or complexity, has a mission or function in the organism biosynthesizing it. In this review, the biological, allelochemical, and chemical properties of acetophenone , as a metabolite involved in multiple interactions with various (mi-cro)organisms, are discussed. Further, the details of its biogenesis and chemical synthesis are provided, and the possibility of its application in different areas of life sciences, i.e., the status quo of ... Acetophenone (C6H5COCH3 ), an organic compound used as an ingredient in perfumes and as a chemical intermediate in the manufacture of pharmaceuticals, resins, flavouring agents, and a form of tear gas. Acetophenone is the organic compound with the formula C6H5C(O)CH3. It is the simplest aromatic ketone. It is a colourless or yellow-tinted liquid with a sweet, strong odour. Acetophenone is an aromatic ketone found naturally in fruits, berries, nuts, and meat. Charles Friedel is credited with the first synthetic preparation of acetophenone by the distillation of a mixture of calcium benzoate and calcium acetate in 1857.