Acivir cream 10 gm contains the active ingredient acyclovir, which belongs to a class of antivirals. This medication treats viral infections such as herpes simplex, which can cause cold sores and genital herpes. Acivir Cream is an antiviral agent used in the management of skin infections caused by the herpes simplex virus-specific cold sores and genital herpes. The active ingredient Acyclovir will decrease the severity and duration of such outbreaks. ZOVIRAX Cream is contraindicated in patients with known hypersensitivity to acyclovir, valacyclovir, or any component of the formulation. Acyclovir cream is a white, odorless, smooth homogeneous cream. Each gram of acyclovir cream contains 50 mg (equivalent to 5% w/w) of acyclovir in an aqueous cream base.