Ambiguous definition: Open to more than one interpretation. Ambiguous definition: open to or having several possible meanings or interpretations; equivocal.. See examples of AMBIGUOUS used in a sentence. AMBIGUOUS meaning: 1. having or expressing more than one possible meaning, sometimes intentionally: 2. having or…. Learn more. However, ambiguous most often describes something that is unclear specifically because it can be understood in more than one way, or because it has more than one possible meaning.