When saying “ Amen ” after hearing G‑d’s praise, one’s intention would be “the blessing that was recited is true and I believe in it,” since the word amen signifies an affirmation of belief. The letters of the word amen are the root letters of the word emunah, meaning belief or trust. The meaning of AMEN is —used to express solemn ratification (as of an expression of faith) or hearty approval (as of an assertion). How to use amen in a sentence. Amen is a word practically everyone has heard and every Christian says in prayer. Discover its origin and meaning of saying " amen " as we look to the Bible for reference. Everyone knows most prayers culminate with an " Amen ." But have you thought about what the word actually means? And why prayers end with it?