Cholestasis is a condition that slows or stops bile flow from the liver to the intestines, leading to jaundice, itching, and other problems. Learn about the different types, causes, and treatments of cholestasis, as well as how it affects pregnancy and liver health. Cholestasis refers to a condition where bile, a digestive fluid produced by the liver, is unable to flow properly into the small intestine. This can occur due to various reasons, including blockages in the bile ducts, liver diseases, or hormonal changes. Understand cholestasis, its symptoms, causes during pregnancy, and how it is diagnosed and treated. In this review, we will discuss some of the atypical causes of cholestatic liver disease such as benign recurrent intrahepatic cholestasis, progressive familial intrahepatic cholestasis, Alagille Syndrome, biliary atresia, total parenteral nutrition induced cholestasis and cholestasis secondary to drug induced liver injury.