Define contamination. contamination synonyms, contamination pronunciation, contamination translation, English dictionary definition of contamination. n. 1. a. The act or process of contaminating. b. The state of being contaminated. 2. One that contaminates. American Heritage® Dictionary of the English... Contamination is the presence of an undesirable element that renders something unsuitable or harmful. Learn about different types of contamination, such as chemical, environmental, radioactive, and interplanetary, and how to detect and prevent them. Master the word "CONTAMINATION" in English: definitions, translations, synonyms, pronunciations, examples, and grammar insights - all in one complete resource. Contamination definition: the act of contaminating, or of making something impure or unsuitable by contact with something unclean, bad, etc.. See examples of CONTAMINATION used in a sentence.