Definition: Disability refers to any condition that significantly limits a person’s ability to perform major life activities. Disabilities can be temporary, long-term, or permanent, and they can affect various aspects of a person’s daily life. The meaning of DISABILITY is a physical, mental, cognitive, or developmental condition that impairs, interferes with, or limits a person's ability to engage in certain tasks or actions or participate in typical daily activities and interactions; also : impaired function or ability. DISABILITY definition: 1. an illness, injury, or condition that makes it difficult for someone to do some things that…. Learn more. DISABILITY meaning: 1. an illness, injury, or condition that makes it difficult for someone to do some things that…. Learn more.