Master the word "ISOLATION" in English: definitions, translations, synonyms, pronunciations, examples, and grammar insights - all in one complete resource. Isolation is the act or state of being separated or cut off from others. It can also refer to a country's withdrawal from international politics, a psychological defense mechanism, or a medical quarantine. ISOLATION meaning: 1. the condition of being alone, especially when this makes you feel unhappy: 2. the fact of…. Learn more. Isolation meanings, definitions, synonyms, and antonym. Explore more Negative Words at Dictionary by BUHAVE. (2025) BUHAVE