The meaning of MUSE is to become absorbed in thought; especially : to think about something carefully and thoroughly. How to use muse in a sentence. Did you know? Synonym Discussion of Muse . MUSE meaning : 1. to think about something carefully and for a long time: 2. a person, or an imaginary being or…. Learn more. Learn the meaning of muse as a verb and a noun, with synonyms, related words and phrases, and examples from the Cambridge English Corpus. Find out how to say muse in different languages, such as Chinese, Spanish, and Portuguese. Definition of muse noun from the Oxford Advanced Learner's Dictionary. a person or spirit that gives a writer, painter, etc. ideas and the desire to create things synonym inspiration . He felt that his muse had deserted him (= that he could no longer write, paint, etc.).