Penile cancer symptoms vary person to person. 1. Change in skin of the penis 2. Wart-like growth or lesion 3. Open sore 4. Reddish rash 5. Small, crusty bumps. Penile cancer is a rare but serious disease that affects the tissues of the penis . It is important to have an understanding of this condition in order to raise awareness and promote early detection and treatment. Penile cancer usually forms on or under the foreskin. Human papillomavirus (HPV) causes about one-third of penile cancer cases. When found early, penile cancer is usually curable. Start here to find information on penile cancer treatment and research. Understand penile cancer with this detailed guide on symptoms, causes, risk factors, diagnosis, and treatment. Learn how early detection improves outcomes.