Learn about the pH of blood , a measure of its acidity or alkalinity, and how the body maintains it within a narrow range. Find out the causes and effects of abnormal pH levels, such as acidosis and alkalosis, and how they affect health. The pH level of blood measures its acidity; healthy humans should maintain a balance around 7.4 on the pH scale. This article will look at what the normal pH level of blood is and what can cause the pH level to move outside of this range. Blood pH Regulation Our body maintains the normal pH by acid-base balance. It is important to maintain homeostasis. There are various factors that regulate blood pH . The pH of blood plasma depends on CO 2, electrolyte and weak acid concentrations. The two main organs that regulate the acid-base balance ( pH ) of the blood are: Lungs- They are in the gaseous exchange and remove CO 2. The brain regulates breathing process so the brain and the lungs maintain blood pH by regulating the speed and ...