Polycystic kidney disease (PKD) is a genetic disease that causes many cysts to grow inside your kidneys. Learn about the causes, symptoms, and treatment for PKD. Information about polycystic kidney disease (PKD), including the symptoms, causes, diagnosis and treatments for it. Polycystic kidney disease (PKD) is a genetic disorder that causes fluid-filled cysts to grow in your kidneys and reduce kidney function. Learn about the types, signs, complications, and ways to slow down PKD from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Learn about polycystic kidney disease (PKD), a genetic disorder that causes cysts to grow in the kidneys and leads to kidney failure. Find out the types, symptoms, complications, diagnosis and treatment options for PKD.