So, end-diastolic volume minus end-systolic volume, gives us the stroke volume, which is the volume of blood that the left ventricle ejects with every heartbeat, or stroke. The definition of stroke volume is the volume of blood pumped out of the heart's left ventricle during each systolic cardiac contraction. The average stroke volume of a 70 kg male is 70 mL. Not all the blood that fills the heart by the end of diastole (end-diastolic volume - EDV) can be ejected from the heart during systole. Introduction: Stroke volume is a critical parameter in cardiovascular physiology that determines the amount of blood ejected by the heart with each contraction. This comprehensive article aims to explore the physiology of stroke volume, including the factors influencing its regulation and its significance in cardiac output. In cardiovascular physiology, stroke volume (SV) is the volume of blood pumped from the ventricle per beat.