Altered sensorium is a neurological deficit that changes the brain function varying from consciousness to coma and death. This study assesses the risk factors, causes, and treatment patterns of altered sensorium in a tertiary care hospital in India. METHODS: The study was conducted on 150 patients with altered sensorium of non traumatic origin, over a period of one year at Koppal Institute of Medical Sciences, Koppal after taking consent from patient relatives and ethical committee clearence. All patients of altered sensorium of non-traumatic origin, aged more than 18 years were include in this study. Glasgow coma scale (GCS) is used for primary assessment and also to compare the outcome. Altered sensorium is a change or disturbance in a person's level of awareness, alertness, or ability to respond to their environment. It can range from confusion and disorientation to unresponsiveness or coma. Learn about the common causes, symptoms, diagnosis, treatment, and prevention of altered sensorium. Cardiac monitoring may be needed in patients who presented with arrhythmias causing hypoperfusion and an acute decline in sensorium (syncope in most cases). Assessing neurological disability ‘D’ is one of the most important steps in the evaluation of patients with altered sensorium.