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antagonist , n. & adj. meanings , etymology, pronunciation and more in the Oxford English Dictionary An antagonist is a character that opposes, competes with, or conflicts with the main character, known as the protagonist, in a story or narrative. Antagonist can mean a person who opposes or disagrees with another, a muscle that performs the opposite action, or a substance that stops a reaction. Learn more about the different meanings and usage of antagonist with examples and translations. Definition , Usage and a list of Antagonist Examples in common speech and literature. Antagonist is a character or a group of characters which stand in opposition to the the main character.