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The meaning of APPETITE is any of the instinctive desires necessary to keep up organic life; especially : the desire to eat . How to use appetite in a sentence. appetite meaning , definition , what is appetite : a desire for food: Learn more. Appetite is a desire for food, drink, or something else. Learn the meaning , pronunciation, and usage of appetite with synonyms, sentences, and idioms from Collins Dictionary. Appetite is the desire to eat food items, usually due to hunger. It is regulated by a close interplay between the digestive tract, adipose tissue and the brain, and can be affected by various factors such as stress, genetics, hormones and diseases.