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Betadine Sore Throat Gargle contains the active ingredient povidone-iodine. Betadine Sore Throat Gargle is a concentrated anti-bacterial formula used as an aid in the treatment of sore throats. Learn about the side effects of Betadine (povidone iodine), from common to rare, for consumers and healthcare professionals. 1. Why am I using Betadine Antiseptic Topical Ointment ? Betadine Antiseptic Topical Ointment contains the active ingredient povidone. Betadine Antiseptic Topical Ointment is used as an antiseptic for the treatment of common skin infections such as infections of the skin around the nails, prevention of infections in minor burns, cuts and abrasions. Compare Betadine head-to-head with other drugs for uses , ratings, cost, side effects and interactions.