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Calamine lotion is an over-the-counter (OTC) medication that can help relieve mild itchiness, or pruritus. It can be used to treat a variety of skin irritations from poison ivy and chigger bites ... Calamine lotion is an astringent used for skin irritation from bug bites, hives, and more. Learn if it could help your itching symptoms and when to avoid it. Calamine is used in the treatment of mild skin irritation and itching conditions. The detailed uses of Calamine are as follows: • Relieves Skin Itching and Irritation: Calamine helps soothe skin irritation and itching caused by rashes, eczema, sunburn, measles, poison ivy, insect bites, and chickenpox spots. • Reduces Oozing and Weeping: Calamine helps dry out oozing or weeping skin conditions such as eczema, insect bites, or minor cuts. Calamine lotion is an over-the-counter medication that relieves itching and discomfort caused by minor skin allergies, such as poison ivy, insect bites, and sunburn.