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The meaning of DIAGNOSIS is the art or act of identifying a disease from its signs and symptoms. How to use diagnosis in a sentence. the process of identifying and determining the nature of a disease or disorder by its signs and symptoms, through the use of assessment techniques (e.g., tests and examinations) and other available evidence. the classification of individuals on the basis of a disease, disorder, abnormality, or set of characteristics. DIAGNOSIS definition: 1. a judgment about what a particular illness or problem is, made after examining it: 2. a…. Learn more. diagnosis (of something) the act of discovering or identifying the exact cause of an illness or a problem. They are waiting for the doctor's diagnosis. An accurate diagnosis was made after a series of tests. They are using new methods of diagnosis.