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Hirschsprung's disease Prevalence: 1 in 3,000 births. Ultrasound diagnosis: The condition is characterized by congenital absence of intramural parasympathetic nerve ganglia in a segment of the colon. The aganglionic segment is unable to transmit a peristaltic wave, and therefore meconium accumulates and causes dilatation of the lumen of the bowel. Learn about the causes, symptoms, diagnosis and treatment of Hirschsprung 's disease , a congenital condition that affects the large intestine. Find out how surgery can help children with this blockage to pass stools normally. Hirschsprung disease (HD) is a congenital disorder defined by the absence of ganglion cells (GC) at the Meissner's plexus of the submucosa and Auerbach's plexus of the muscularis in the terminal rectum that extends in a variable distance proximally.[1] Its prevalence varies from 1 to 1.63 per 10,000 births.[2] Introduction Hirschsprung Disease is a congenital condition that affects the large intestine, leading to significant challenges in bowel function. This condition is characterized by the absence of nerve cells (ganglia) in a segment of the bowel, which disrupts normal peristalsis—the wave-like muscle contractions that move food through the digestive tract. Understanding Hirschsprung Disease is crucial, as early diagnosis and treatment can significantly improve the quality of life for ...
