Sodium is a dominant cation in extracellular fluid and is necessary for the maintenance of intravascular volume. The human body maintains sodium and water homeostasis by concentrating the urine secondary to the action of antidiuretic hormone (ADH) and increased fluid intake by a powerful thirst response. These mechanisms to protect against developing hypernatremia are impaired in certain vulnerable populations, vasopressin deficiency, or unresponsiveness at the renal tubular level ... Hypernatremia is a high concentration of sodium in the blood that can affect brain function and cause dehydration. Learn about the common causes, such as low or high fluid intake, diabetes insipidus, and salt poisoning, and how to diagnose and treat this condition. Hypernatremia is a condition where sodium levels in the blood are too high. It can result from dehydration, fluid loss, or certain health issues. Learn about the causes, symptoms, diagnosis, treatment, and prevention of hypernatremia. Hypernatraemia can be caused by a number of critical illnesses: water depletion (decreased intake, hypotonic fluid loss – renal/non-renal); solute excess (Na+ or other)

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