Ibuprofen reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI). Naproxen and ibuprofen are both NSAIDs, but which one is more effective or more likely to cause side effects? Ibuprofen is short acting, while naproxen is long acting and more likely to cause gastrointestinal side effects, such as an upset stomach or bleeding in the stomach. Naproxen also increases the risk of uncontrolled bleeding in people taking blood thinners by 4-fold, and ibuprofen increases the risk 2-fold. Taking NSAIDs with blood thinners triples the risk of anemia. NSAIDs are not ... Easy-to-read patient tips for ibuprofen covering how it works, benefits, risks, and best practices. Aleve and ibuprofen are both used for pain relief. But is one more effective or more likely to cause side effects compared to the other? One of the most important differences between Aleve and ibuprofen is the length of time they act for. Ibuprofen is short-acting and is better suited for the treatment of acute pain, whereas Aleve is long-acting and is used for the treatment of chronic conditions. Aleve is more likely than ibuprofen to cause gastrointestinal (GI) side effects because it is ...

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