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Iran 's state news agency IRNA said Tehran launched hundreds of ballistic missiles at Israel after Israel blasted Iran 's huge Natanz underground nuclear site and killed its top military commanders. It was the second direct attack by Iran against Israel , the first being the April 2024 strikes. Iran claimed that the attack was an act of "self-defense" [19][20] in retaliation for Israel 's assassinations of Hamas leader Ismail Haniyeh in Tehran, Hezbollah leader Hassan Nasrallah, and IRGC general Abbas Nilforoushan. It started when Israel attacked nuclear and military sites in Iran , and then Iran retaliated with aerial attacks targeting Israel . Strikes hit central and north Israel as the Israeli military carries out further attacks in Iran .