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Melancholy is a feeling of sadness, gloom, or pensive reflection. It can also refer to a humor or a bodily fluid associated with depression. Find out more about the origin, usage, and related terms of melancholy . Melancholy definition: a gloomy state of mind, especially when habitual or prolonged; depression.. See examples of MELANCHOLY used in a sentence. The meaning of MELANCHOLY is a state of sadness : depression of spirits : dejection. How to use melancholy in a sentence. The noun ' melancholy ' has its etymological origins in Greek and later Latin. It comes from the Greek word 'melankholia,' which is a combination of 'melas,' meaning 'black,' and 'kholē,' meaning 'bile.' In ancient Greek medicine, it was believed that an imbalance in the bodily fluids, particularly an excess of black bile, could lead to a person's disposition becoming excessively sad or gloomy. This idea was later adopted by Roman physicians, who referred to this condition as 'melancholia ...