Learn about the geography, counties, and major cities of Missouri , a state in the central United States. Explore maps of Missouri 's regions, rivers, lakes, and borders with other states. Ready to chase your curiosity? At the University of Missouri , we’ve maintained a nearly 200-year reputation for the Missouri Method, our signature approach to hands-on learning through research, internships and other experiential settings. We're not just shaping future leaders here. By bringing together the nation’s best students, world-class faculty and a unique infrastructure for innovation, we're building a brighter future for Missouri and beyond. So, get ready to embrace the ... Missouri is a state in the Midwestern region of the United States. It was acquired from France as part of the Louisiana Purchase in 1803 and was admitted into the Union as the 24th state in 1821. Missouri is a major center of beer brewing and has some of the most permissive alcohol laws in the U.S. [10] It is home to Anheuser-Busch, the world's largest beer producer, and produces Missouri wine, especially in the Missouri Rhineland.