Mitigation is the reduction of something harmful or its harmful effects. It can apply to various fields such as disaster, environment, law, information technology and occupational safety. Learn more about the principles, methods and applications of mitigation . MITIGATE definition: 1. to make something less harmful, unpleasant, or bad: 2. to make something less harmful…. Learn more. Explore the term ' mitigation ,' its meanings, etymology, and application in various fields such as risk management and environmental science. Understand how mitigation strategies are crucial for reducing negative impacts. The meaning of MITIGATION is the act of mitigating something or the state of being mitigated : the process or result of making something less severe, dangerous, painful, harsh, or damaging. How to use mitigation in a sentence.