Methicillin-resistant Staphylococcus aureus, commonly known as MRSA, represents a formidable challenge in the world of infectious diseases due to its resistance to numerous antibiotics. Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most successful modern pathogens. The same organism that lives as a commensal and is transmitted in both health-care and community settings is also a leading cause of bacteraemia, ... MRSA is mediated by the mecA gene; which is chromosomally coded. It alters penicillin-binding protein (PBP) present on S. aureus cell membrane to PBP-2a: PBP is an essential protein needed for the cell wall synthesis of bacteria. β lactam drugs bind and inhibit this protein, thereby inhibiting cell wall synthesis. The altered PBP2a of MRSA strains has less affinity for β lactam antibiotics; hence MRSA strains are resistant to all β lactam antibiotics. BORSA strains (Borderline Oxacillin ... MRSA (methicillin-resistant Staphylococcus aureus) is a type of bacteria that many antibiotics don’t work on. MRSA can cause serious illness that’s hard to treat.
