Dermatomyositis (dur-muh-toe-my-uh-SY-tis) is a condition in which swelling and irritation, called inflammation, attacks the body's tissues. Dermatomyositis causes muscle weakness and a skin rash. The condition, also called an autoimmune condition, isn't common. It can affect adults and children. In adults, dermatomyositis most often happens in the late 40s to early 60s. In children, it most often appears at ages 5 to 15. There's no cure for dermatomyositis. But treatment can improve muscle ... Myositis is a group of inflammatory, immune-mediated disorders that cause muscle weakness, fatigue, and difficulty with daily activities. Polymyositis Polymyositis is a rare disease that makes your immune system attack your muscles. It causes inflammation and weakness in muscles close to the center of your body, which can lead to severe, life-threatening complications. Visit a healthcare provider if you notice new muscle weakness, pain or fatigue. Myositis is a disease that makes your immune system attack your muscles, causing inflammation and weakness. Learn about the different types of myositis, how they’re diagnosed and treated, and what complications they can cause.