Phosphorylation: Is adding a phosphate

Phosphorylation is adding a phosphate group to an ion or molecule, which is important for energy, signaling, and protein regulation. Learn about glucose, protein, and oxidative phosphorylation, and how to detect and study phosphorylation. In this article we will discuss about:- 1. Introduction to Phosphorylation 2. Definition of Phosphorylation 3. Physiological Importance 4. Control. Introduction to Phosphorylation: Certain organic phosphates, formed in the tissues out of anabolic chemical reaction, play a key role in the energy transactions of living organisms. The importance of organic phosphates in metabolism was first indi­cated by the studies of Harden and Young, who found that fermentation of glucose by cell-free yeast ... Substrate Level Phosphorylation The easiest type of phosphorylation to understand is that which occurs at the substrate level. This type of phosphorylation involves the direct synthesis of ATP from ADP and a reactive intermediate, typically a high energy phosphate-containing molecule. Substrate level phosphorylation is a relatively minor contributor to the total synthesis of triphosphates by cells. An example substrate phosphorylation comes from glycolysis. Figure 2 6 1: Adenine nucleotides ... Reversible protein phosphorylation, principally on serine, threonine or tyrosine residues, is one of the most important and well-studied post-translational modifications. Phosphorylation plays critical roles in the regulation of many cellular processes including cell cycle, growth, apoptosis and signal transduction pathways. Phosphorylation is the most common mechanism of regulating protein function and transmitting signals throughout the cell. While phosphorylation has been observed in ...