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Key Takeaways Polycystic ovary syndrome , or PCOS, is a condition that affects the endocrine, reproductive and metabolic systems and involves symptoms like irregular periods, acne, infertility ... Introduction Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women of reproductive age, affecting 10% of women. 1 The pathophysiology of PCOS involves excessive androgen production and multiple ovarian cysts. Consequently, the main clinical features include anovulatory infertility, acne and hirsutism, irregular menstrual cycles, obesity and increased long term risks of cardiovascular events and endometrial cancer. Learn about PCOS, a hormonal imbalance that affects your ovaries, periods, fertility and more. Find out the causes, diagnosis, treatment and prevention of this common condition. Polycystic ovary syndrome (PCOS) is a hormonal disorder that affects people with ovaries. PCOS causes hormonal imbalance and metabolism problems; it may lead to infertility. PCOS affects about 1 in 10 adults with ovaries.