Portal hypertension: Causes

Portal Hypertension : Causes, Symptoms and Treatment Portal hypertension occurs when there is increased pressure in the portal vein, which carries blood from the intestines to the liver. This elevated pressure can lead to serious complications over time. One of the main causes of portal hypertension is liver cirrhosis, a condition where healthy liver tissue is replaced by scar tissue. Other causes include blood clots in the portal vein, liver infections, and certain genetic disorders. When ... Portal hypertension is defined as a hepatic venous pressure gradient (HVPG) >5 mmHg, which is a surrogate for the portosystemic pressure gradient. Clinically significant portal hypertension is defined as a gradient >10 mmHg, and variceal ble... What is Portal Hypertension ? This information is intended to help you understand: The liver and its function. Portal hypertension , also known as high blood pressure in the portal vein of the liver. The complications — varices, ascites and hepatic encephalopathy — caused by portal hypertension . Signs and symptoms that require immediate medical attention. Possible treatment options. If you have questions about the information in this booklet or your health condition, testing or treatment ... Chronic liver disease (CLD) imposes a major global health burden, with portal hypertension (PH) and its complications driven by complex pathophysiological mechanisms. Understanding these processes is essential for effective therapy. The hepatic venous pressure gradient (HVPG) is the gold standard for assessing portal hypertension , providing key diagnostic, prognostic, and therapeutic guidance—particularly in distinguishing its type and monitoring response to treatments such as non ...