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Promethazine, sold under the brand name Phenergan among others, is a first-generation antihistamine, sedative, and antiemetic used to treat allergies, insomnia, and nausea. Promethazine is used in the treatment of nausea, vomiting, vertigo, allergic conditions, appetite stimulant, morning sickness and motion sickness. It is also used for short-term treatment of insomnia (difficulty sleeping) in adults and as a sedative in children aged 5 years and above. Promethazine hydrochloride tablets are contraindicated for use in pediatric patients less than two years of age. Promethazine is contraindicated in comatose state, and in individuals known to be ... Promethazine hydrochloride is a phenothiazine used to treat or prevent nausea and vomiting caused by anesthesia or surgery, certain types of allergic reactions, pain caused by surgery or childbirth, and to sedate patients before surgery or medical procedures.