PROMISCUOUS meaning : 1 : having or involving many sexual partners; 2 : including or involving too many people or things not limited in a careful or proper way The meaning of PROMISCUOUS is having or involving many sexual partners : not restricted to one sexual partner or few sexual partners. How to use promiscuous in a sentence. The Multiple Meanings of Promiscuous The adjective promiscuous is often used pejoratively to refer to someone who has many romantic partners. However, the word can also be used in a general sense to mean "not limited, restrained, or restricted." If you're a promiscuous reader, you'll read just about anything — from biographies to science fiction to the back of the cereal box. PROMISCUOUS meaning : 1. (of a person) having a lot of different sexual partners or sexual relationships, or (of sexual…. Learn more.