Proteinuria identifies patients with kidney damage and those at risk for worsening kidney disease and increased cardiovascular morbidity. An individual with proteinuria in the setting of a normal glomerular filtration rate (GFR) is at high risk of progressive loss of kidney function. Temporary proteinuria may occur after vigorous exercise or if you have a high fever. Sometimes, almost always in children, proteinuria can be detected later in the day, but not in the morning. This is known as orthostatic proteinuria and it is usually harmless. Proteinuria - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the Merck Manuals - Medical Professional Version. Proteinuria is a medical condition characterized by the presence of excess protein in the urine. While the kidneys typically filter waste products from the blood, they also retain essential proteins. When this filtration process is disrupted, proteins can leak into the urine, leading to proteinuria.