Rifampin, also known as rifampicin , belongs to the antimicrobial class of drugs. This medication is used to manage and treat diverse mycobacterial infections and gram-positive bacterial infections. Overview: Rifampin is used to treat tuberculosis and to get rid of meningitis-causing bacteria in your nose or throat. Common side effects include nausea, vomiting, diarrhea, and upset stomach.... What is rifampin, and what is it used for? Rifampin is a semisynthetic antibiotic used to treat latent or active tuberculosis, a disease caused by mycobacterial infection, and the asymptomatic carrier state of meningococcal disease. Rifampin is an antibiotic used alone or in combination with other antimicrobial drugs to treat tuberculosis and asymptomatic carriers of Neisseria meningitidis.