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Sanguine definition : Cheerfully confident; optimistic.Origin of Sanguine From French sanguin, ultimately from Latin sanguineus (“of blood" ), from sanguis (“blood" ), of uncertain origin, perhaps Proto-Indo-European "h₁shâ‚‚-én-, from "h₁éshâ‚‚rÌ¥ (“blood" ). From Wiktionary Middle English blood-red, dominated by the humor blood, ruddy from Old French sanguin from Latin sanguineus bloody, blood-red from sanguis sanguin- blood From American Heritage Dictionary of the ... SANGUINE meaning : 1. (of someone or someone's character) positive and hoping for good things: 2. red in colour: 3…. Learn more. Define sanguine . sanguine synonyms, sanguine pronunciation, sanguine translation, English dictionary definition of sanguine . adj. 1. a. Cheerfully confident; optimistic: sanguine about the prospects for an improved economy. b. At ease; accepting: "Deborah was generally sanguine ... SANGUINE definition : 1. (of someone or someone's character) positive and hoping for good things: 2. red in colour: 3…. Learn more.