Sickle cell disease (SCD) is a hereditary blood disorder characterized by the production of abnormal hemoglobin molecules that cause red blood cells to take on a crescent or sickle shape. This condition affects millions of people worldwide, ... Sickle cell disease is a group of inherited disorders that affect the hemoglobin, which causes sickle-shaped red blood cells. Learn about the symptoms, causes and treatment. Sickle-cell disease is a serious inherited blood disorder caused by a mutation in the HBB gene, leading to abnormal, sickle-shaped red blood cells that block blood flow and cause severe health complications. Sickle cell disease is a group of inherited conditions that affect the red blood cells and cause pain, infection and anaemia. Learn about the symptoms, causes, diagnosis, treatment and outlook for sickle cell disease and how to live with it.