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Breast tenderness is the sensitivity or discomfort felt in the breasts, often due to hormonal changes. Learn about the causes, risk factors, diagnosis, treatment, and preventive measures for this condition. Breast pain is any discomfort, tenderness, or pain in the breast or underarm region, and it may occur for a number of reasons. Breast pain usually isn’t a sign of breast cancer. Sore breasts or mastalgia is tenderness, throbbing, sharp, stabbing, pain or tightness in the breast tissue. Learn about its causes, symptoms & treatments! Breast pain can be cyclical and related to the menstrual cycle — or not. Learn the different types of breast pain and when to see a doctor.