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Vain is from Latin vanus, "empty," and in English it originally meant "lacking value or effect, futile," like your vain attempt to find a pencil in your messy, overstuffed backpack. Likewise, the phrase "in vain " means "without success." Vain also means "conceited, too proud of oneself." VAIN meaning : 1. unsuccessful; of no value: 2. unsuccessfully: 3. too interested in your own appearance or…. Learn more. Definition of vain adjective in Oxford Advanced Learner's Dictionary. Meaning , pronunciation, picture, example sentences, grammar, usage notes, synonyms and more. Vain can mean unsuccessful, of no value, or too proud of yourself. Learn how to use it in different contexts with synonyms, antonyms, and examples from the Cambridge Dictionary.