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The Venereal Disease Research Laboratory ( VDRL) test is a blood test used to detect the presence of antibodies that are produced by the body in response to certain infections, primarily syphilis. Syphilis is a sexually transmitted infection (STI) caused by the bacterium Treponema pallidum. The VDRL test is a non-specific test , meaning it can detect antibodies produced in response to various conditions, not just syphilis. It is classified as a nontreponemal test because it doesn’t directly ... Get a complete guide to the VDRL test . Understand its full form, meaning, and how to interpret your results for accurate health insights. The VDRL test is a nontreponemal serological screening for syphilis that detects anti-cardiolipin antibodies. It has high sensitivity, but can be affected by other medical conditions and requires more specific tests for confirmation. The Venereal Disease Research Laboratory test (VDRL) is a screening test for sexually transmitted infection – syphilis caused by the spirochete bacterium Treponema pallidum.